3/29/2024 0 Comments Skin goat infectionsSince May 2022, nearly 90,000 cases of mpox have been reported within a global outbreak, with the major proportion of cases affecting men who have sex with men. This case of mpox-associated encephalitis shows that CNS involvement in mpox infection may have a relatively mild clinical course, and that detection of intrathecal antibody production can be used to establish the diagnosis if CSF monkeypox virus-PCR is negative. He spontaneously improved over a few days course and recovered fully. The CSF was PCR-negative for monkeypox virus but intrathecal antibody production was detected. Neuroimaging and CSF analysis indicated encephalitis. Twelve days later he was admitted with fever and confusion. He first presented with painful skin lesions and genital ulcers polymerase chain reaction (PCR) from the lesions was positive for mpox. We report a previously healthy 37-year-old man with mpox complicated by encephalitis. ![]() Central nervous system (CNS) involvement has previously been described as a rare and severe complication of mpox however, diagnostic findings in cerebrospinal fluid (CSF) analysis and neuroimaging studies have only been reported in one case previously. In the 2022 mpox-outbreak most patients presented with mild symptoms.
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